Reviewed by Evan Lewis, PhD. Last updated 10 August 2026.
Short answer: use them at opposite ends of the day. Apply Jublia at night so it has 8 to 10 undisturbed hours on the nail, and do your IodinePure soaks and sprays in the morning or daytime. Never apply IodinePure right after Jublia, because iodine can break the medicated film down before it has had time to absorb.
What is Jublia?
Jublia (efinaconazole 10%) is a prescription topical solution that you brush onto the toenail once a day. It is designed to stay on the nail and absorb over time, and courses often run many months: in the two pivotal trials reviewed by CADTH the treatment period was 48 weeks, with complete cure reported at 17.8% and 15.2% at week 52. Because it needs uninterrupted contact to do its job, what you put on the nail around it, and when, matters.
Can you use IodinePure with Jublia?
Yes, as long as you separate them by several hours. IodinePure EZ Clear Nails is a natural, aqueous (water-based) iodine routine that supports the look of clearer nails and makes a daily habit easy to keep.
The key is timing. Iodine is a strong oxidiser: a 2020 review describes it as rapidly penetrating microorganisms and oxidizing key proteins, nucleotides, and fatty acids. That same chemistry can break down a freshly applied efinaconazole film before it absorbs. So the two should never go on back to back.
What does the daily schedule look like?
Green in the daytime, blue at night, and a long gap in between.
Opposite ends of the day, with hours in between. That gap is the whole point.
- Night: apply Jublia to a clean, dry nail exactly as directed, and let it sit undisturbed for 8 to 10 hours while you sleep.
- Morning or daytime: do your IodinePure routine. Spray the nail twice daily, and soak in the kit's tray for 5 to 7 minutes, 3 to 4 times a week.
- Never: apply IodinePure over freshly applied Jublia, or apply Jublia straight after an iodine soak. Keep them hours apart.
Where does the soak reach that a brush-on cannot?
Underneath, and around the sides. Jublia is brushed onto the top of the nail, so it works on the surface it can reach.
The IodinePure soak works from a different angle. Three to four times a week the aqueous iodine surrounds the toe, so it travels under the free edge and around the nail folds rather than sitting on top, and the twice-daily spray keeps the surface and the surrounding skin covered between soaks. That all-round coverage, and the support it gives the healthy-looking skin around the nail, is what a surface-only application cannot do.
Your 90-day EZ Clear Nails Kit already includes the spray bottle, so you mist your nails morning and night and spray the inside of your shoes to keep the whole environment clean. That last step is worth doing: a review of shoe and sock sanitisation reported recurrence and relapse rates for superficial fungal infections of the feet of 10% to 53%.
Toenails also grow more slowly than the number most articles quote. The 3mm a month figure is the fingernail rate, while toenails were measured at about 1.62 mm a month. That is why a full great toenail takes roughly 12 to 18 months to replace itself, and why consistency over that stretch is what wins. Curious how the two stack up on their own? See our Jublia vs. IodinePure comparison.
What should you expect over the months?
A millimetre or two, and then patience. New growth from the base is small in the first month, so don't judge progress too early. By around 60 to 90 days, many people start to see clearer new growth at the base as the older portion grows out toward the tip. Keep both parts of your routine consistent well past 90 days.
Follow your prescriber's instructions
Jublia is a prescription product, so use it exactly as your prescriber or pharmacist directs and tell them what else you are putting on the nail. Book in with a foot care professional rather than starting at home if a nail is painful, lifting away from the nail bed, if there is a dark streak running from the cuticle to the tip, or if you live with diabetes or poor circulation. Your prescription and your daily routine are doing different jobs at different times of day, which is exactly why the timing above matters.
Frequently Asked Questions
Can I use iodine with Jublia?
Yes, as long as you keep them hours apart. Apply Jublia at night and do your IodinePure soaks and sprays in the morning or daytime.
Why can't I apply IodinePure right after Jublia?
Iodine is a strong oxidiser and can break down the efinaconazole film before it has absorbed, which works against the Jublia. Always separate them by several hours.
When should I apply Jublia versus IodinePure?
Jublia at night for 8 to 10 undisturbed hours, IodinePure in the morning or daytime.
How does IodinePure fit alongside Jublia?
They occupy different parts of the day and reach different parts of the nail. Jublia is brushed on at night and absorbs into the nail surface. The IodinePure soak surrounds the toe in the morning, carrying aqueous iodine under the free edge and around the nail folds, and the spray covers the nail and surrounding skin twice a day. Keep taking your prescription exactly as directed and let the daily routine cover the hours in between.
How long until I see clearer-looking nails?
Toenails grow about 1.62 mm a month, so clearer new growth usually becomes visible over several months, with a full great toenail taking roughly 12 to 18 months to grow out completely.
Related reading
- Using IodinePure with Toe FX: fitting your routine around clinic light therapy
- Jublia vs. IodinePure: what the research shows about each option
- Best toenail fungus treatment in Canada (2026): the options compared
Build Your Daily Nail Routine
IodinePure EZ Clear Nails is a complete natural aqueous iodine kit: the soak solution, the soak tray, and a refillable spray bottle for misting your nails twice daily and freshening the inside of your shoes. Because you soak as well as spray, the iodine reaches under the free edge and around the nail folds, not just the surface. Listed with Health Canada as a cosmetic, made with two natural ingredients, and carried by over 200 foot care clinics across North America.
This article was reviewed by Evan Lewis, PhD, who specialises in natural and nutritional therapies for the prevention and management of chronic disease.
